The No Doubt songstress wore a black cut-out maxi-dress which she paired with purple fishnet sleeves.
Gwen also drew attention to her eyes with thick flicked eyeliner and lashes, giving her a fresh, fun demeanour.
The GXVE Beauty creator told the host: "I have done my own make-up all of my life."
The Don't Speak hitmaker chatted with the host about her career, but her appearance left some fans distracted as she flaunted her youthful looks.
Commenting on a YouTube clip of the interview, one person said: "I’m a lifelong fan of Gwen’s and I didn’t recognise her. I’m so confused."
Another fan wrote: "Would never have known this was Gwen Stefani without the title!"
While a third added: "She’s literally unrecognisable."